Asseverator , 17 August UTC. Can i request for a section which will talk about the mechanism this virus uses in infection. Also, if anyone is talented enough, can we have a Flash movie about how the virus infect the cels and then spread??
This subject has been in the news the past few weeks and I imagine that many dog owner are as concerned as I am. Perhaps someone more learned than I can write a section on this subject? Elipongo , 21 October UTC. Treatment of the symptoms people. Proposed sections moved from this talk page to Flu treatment. This article is already too long to signifiantly expand any sections, but each section can be expanded in a related article and linked as appropriate.
Please feel free to add to Flu treatment. WAS 4. I see that this article has references, but there are no footnote markers, so just by reading the article, you can't tell which reported facts are supported by which sources. More importantly, you can't tell which reported facts are unreferenced, and this need checking up on.
Editors with access to these sources are needed to fix this. Because of concerns ranging from verifyability to understandability I moved the following from the article to here:. I thought "why wait for him to teach me" so I read Morpholino and thought its connection to influenza rather weak, so the possibility of spamming a special interest occured to me, so i went to your user page, saw you were trying to blank it, looked at it history, and saw that your first uer page said:.
All of which makes me believe you can usefully help out wikipedia but the influenza article may not be the best place for it. It has the unfortunate appearance of helping yourself more than helping the encyclopedia. Best of luck making money. I do intend to feed and educate my daughters. However, I am an advocate for the technology, which holds the promise of broad antiviral applications, anticancer applications and soon-to-begin clinical trials for Duchenne's Muscular Dystrophy.
Details of Morpholino antisense are in the Morpholino article; I originally only posted information directly relevant to influenza and verifiable in the scientific literature. Per your request, I offer more support here for efficacy of Morpholinos against influenza. I originally hesitated to bring in sources such as conference reviews or company press releases, as I prefer to rely on more traditional scientific citations.
I think a shorter mention of the studies with pointers to articles with more information is more appropriate. However, the following expanded discussion does present a clearer view of the potential of this technology specifically as an influenza therapeutic. Preclinical research with Morpholino antisense oligos has shown efficacy of the antisense against influenzavirus in cell cultures.
Cultures of African green monkey kidney cells vero cells were pretreated with Morpholino antisense oligos conjugated with arginine-rich peptides to enhance penetration of the oligos into the cytosol. Targeting translation-blocking Morpholinos against the nucleoprotein 1 mRNA or one of the polymerase protein mRNAs caused log10 reductions in influenzavirus titer three days post-infection. When Morpholinos were administered post-infection, less antiviral activity was measured.
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Frederick G. Inhibition of influenza A virus production in vero cells with morpholino oligomers. Abstract V AVI BioPharma reports that when tested against several influenza strains by several independant laboratories, Morpholino oligos have suppressed viral replication and in one cse both replication and transcription were repressed. You aren't spamming this stuff all over, the data seems real, you seem honest;so, I would love to help you get the relevant data in the relevant articles.
My career before I retire was a little in physics and a lot in computer science, reading lots of everything over the decades in numerous firlds. Lately, I've read everything I could about H5N1. But since this is your area of expertise why don't you set up a work space at your user page where sources, quotes from sources, explantions of the quote, articles to put the data can be worked on. I'm hoping others can join over time in such an enterprise I'm sure you are aware we don't do original research, so no matter how true it is we can't use it without an unbiased verifyable source.
With regard to "the following expanded discussion"; give me 24 hours to digest it. Very good. I won't post directly to Influenza; that has been my behavior since you originally removed the link and I will continue to limit my influenza posts to the discussion here. I think it is wise, "providing a conflict of interst buffer to avoid the appearance of impropriety". You have all I have as far as links to sources in the expanded article. I am happy to help with interpretation. I'll check back Monday.
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Jon 24 March I've done sundry things you can check out with the "User contributions" link at the far left on my user talk page; but as far as the above is concerned, I can't figure out any way to justify putting it in influenza. It is very technical reseach that needs to go in a technical article or an article like spanish flu that is short enough a little research data doesn't hurt.
The H5N1 doesn't really go here except people are confusing human and bird influenza and we don't have a bird influenza article, so we make do Get your bosses to get a newspaper to claim it is a noteable example of influenza reseach backed with data not just a free lunch and a short influenza research subsection here could mention Morpholinos.
This article does need a short section on influenza reseach and if you were to write it not giving undo emphasis to your favorite topic, it could work - but I see no evidence any mention of Morpholinos in a short section trying to cover all influenza research would not be giving it undue emphasis. So were does it fit? How about Cell culture? I'll see what I can do about putting Morpholinos cell culture research data there.
After you look at it tell me what you think. Putting influenza knockdown information into the cell culture article isn't a good fit, since there are hundreds of cell culture papers in the primary literature using Morpholino oligos against a broad range of cellular genes as well as some viral targets -- mentioning one of these hundreds of reported knockdown targets in the cell culture article is not a balanced presentation of the use of Morpholino technology in cell culture.
If you don't feel that influenza gene knockdown information is a good fit in the influenza article I won't keep arguing for that. As you suggest, wait for the newspapers. Jon 28 March This article doesn't say where epidemic flu strains originate.
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I've heard that they originate in poultry in Southeast Asia, but I don't know for sure, and I'd like to know more. The genotype H5N1 has been known for decades. The current pandemic threat strain of H5N1 emerged through reassortment in from earlier highly pathogenic genotypes of H5N1 that first appeared in China in in birds and in Hong Kong in in humans. Are the origins of epidemic flu strains usually known? Decades ago, sometimes flu would be worse someplaces than others or the flu season would start earlier someplaces and people assumes the bug started "there".
In the "Spanish flu" the world was at War WWI , most nations including the US had significant press censorship; Spain did not have press censorship; so the first nation to widely publish facts about a pandemic was Spain, so many assumed it came from "there". In fact it started in America. The bottom line is that before we were able to genetically sequence the virus people just guessed and believed what made them feel good: it came from them over there.
Today with modern gene sequencing we can figure out the specific strains and their relationships to prior strains but no one knows in which individual or on what day the strains mutated into the latest strain. Its just not knowable. None the less, people guess and believe what makes them happy. The Chinese government wants to believe the latest H5N1 deadly strain did not come from China. The evidence is that it originated in south China in the late s in chickens. Even if true futher pinning it down is next to impossible as to either date or place.
Strains that are the garden variety yearly human flu "originate" in humans; being passed human to human, always geneticly drifting like asking where wind originates. Pandemic versions usually result from reassortment in either humans or pigs. H5N1 was the first time we became aware of the possibility genetic drift in birds could produce a pandemic strain.
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This was a suprise both because it was assume drift wasn't enough, it had to be genetic shift to be a pandemic. And it was a surprise because it was considered a fact that a virus endemic in wild birds had to first become pathogenic in chickens, then spread to pigs and reassort with human flu strains in pigs swine flu in order to create a flu pandemic.
This can do it; but now we know there are other paths to a flu pandemic. With this new knowledge scientists reviewed data on the spanish flu virus and have decided they don't know where it came from - not the species human, pig, bird, or unknown other all have their proponets nor whether it was a reassortment or not before, it was assumed to be a reassortment; probably in a pig.
Perhaps the following citation is factually correct, but I find stating this as one of the main problems created by flu somewhat disturbing:. The disease is caused by the viurus so it seems odd not to have any discussion of the causative agent. There isn't even a short summary or any easy links to an explanation of the virus. In fact I've been looking through other pages and have found no explanation of the life cycle of the virus, very little of what the virions are. If I was wanting to find information about influenza, I would find it very hard to find out about the virus itself.
I am going to reinstate my addition, with some tweaking to respect the article is predominantly about the disease. A virus is one type of microscopic parasite that infects cells in biological organisms. The Orthomyxoviridae are a family of RNA viruses which infect vertebrates.
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It includes those viruses which cause influenza. Viruses of this family contain 7 to 8 segments of linear negative-sense single stranded RNA. This is not a phylogenetics based taxonomic category. HA, NA, and M specify the structure of proteins that are most medically relevant as targets for antiviral drugs and antibodies. This segmentation of the influenza genome facilitates genetic recombination by segment reassortment in hosts who are infected with two different influenza viruses at the same time .
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